基本信息：
姓 名：卢言慧
毕业院校 ：首都医科大学
学 历：博士研究生
专 业：营养与食品卫生学博士；护理学博士后
所属教研室：内外科护理学教研室
职称/职务：研究员，硕/博士生导师，博士后合作导师
电 话：010-82805228
邮 箱：luyanhui@bjmu.edu.cn
科研项目：
2025-01至2028-12国家自然科学基金（面上项目）：肠道Akk菌源性维生素B12通过调控神经细胞重编程改善糖尿病认知障碍的作用及机制，主持。
2023-10至2025-10军委科技委项目：未来先进技术，主持。
2024-01至2026-12国家自然科学基金（集成项目）：肠道菌群对代谢性疾病的调控作用与干预策略研究，骨干。
2022-12至2027-12科技部“干细胞研究与器官修复”重点专项项目：母胎耐受机制及其在干细胞移植免疫耐受诱导中的应用，骨干。
2023-01至2023-12北京大学临床医学+X青年专项：肠道菌群代谢物乙酸通过泛素化-线粒体自噬途径调控NLRP3炎症小体改善糖尿病认知功能障碍机制研究，主持。
2021-01至2023-12国家自然科学基金（青年项目）：Akk菌通过调控NLRP3炎症小体改善2型糖尿病所致认知功能障碍的作用及其机制，主持。
2018-05至2021-01博士后课题基金一等资助：核糖糖基化对2型糖尿病患者认知功能的影响及机制研究。
2019-01至2020.12北京市自然基金青年项目：肠道菌群代谢产物短链脂肪酸在2型糖尿病所致认知功能障碍中的作用及机制研究。
2018-05至2020-05 北京大学朗泰护理科研基金项目：肠道菌群及其代谢产物在2型糖尿病所致轻度认知功能障碍中的作用。
发表文章：
Tingjing Zhang, Jiangen Song, Zhenfei Shen, Kewan Yin, Feifei Yang, Honghao Yang, Zheng Ma, Liangkai Chen, Yanhui Lu*, Yang Xia*. Associations between different coffee types, neurodegenerative diseases, and related mortality: findings from a large prospective cohort study. The American Journal of Clinical Nutrition. 2024 Aug.
Limin Cao, Yu An, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu*, Liangkai Chen*, Yang Xia*. Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis. BMC Medicine. 2024, 22:101.
Tingjing Zhang, Yu An, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu*, Yang Xia*. Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank. Alzheimer's research & therapy. 2024 May 11;16(1):106.
Yage Du, Yu An, Ying Song, Nan Li, Jie Zheng, Yanhui Lu*. Live and pasteurized Akkermansia muciniphila ameliorates diabetic cognitive impairment by modulating gut microbiota and metabolites in db/db mice. Experimental Neurology. 2024 May 21:114823.
Zhaoming Cao, Yu An, Yanhui Lu*. Altered N6-methyladenosine modification patterns and transcript profiles contributes to cognitive dysfunction in high-fat induced diabetic mice. International Journal of Molecular Sciences. 2024 Feb 6;25(4):1990.
Xin Zhang, Tianzhi Xie, Shuang Zhou, Yingxuan Yuan, Weixuan Chen, Jie Zheng, Xuebo Liu, Tian Yuan*, Yanhui Lu*, Zhigang Liu*. Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids. Food & Function. 2024 Feb 19;15(4):2249-2264.
Jie Zheng#, Yu An#, Yage Du, Ying Song, Qian Zhao, Yanhui Lu*. Effects of short-chain fatty acids on blood glucose and lipid levels in mouse models of diabetes mellitus: a systematic review and network meta-analysis. Pharmacological Research. 2024 Jan;199:107041.
Yage Du, Liuqing Yang, Yu An, Ying Song, Yanhui Lu*. Health-related quality of life and associated factors in elderly individuals with dyslipidemia in rural Northern China. Quality of Life Research. 2023 Dec;32(12):3547-3555.
Chunyou Mao*, Mengru Gao, Shaokun Zang, Yanqing Zhu, Dandan Shen, Linan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Weiwei Wang, Qingya Shen, Yanhui Lu*, Xin Ma*, Yan Zhang*. Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nature Communications. 2023 Nov 22;14(1), 7620.
Yage Du, Qi Zhang, Xiaolan Zhang, Ying Song, Jie Zheng, Yu An*, Yanhui Lu*. Correlation between inflammatory biomarkers, cognitive function and glycemic and lipid profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Clinical Biochemistry. 2023 Nov; 121-122:110683.
Ying Song, Fangxiao Cheng, Yage Du, Jie Zheng, Yu An, Yanhui Lu*. Higher adherence to the AMED, DASH, and CHFP dietary patterns is associated with better cognition among Chinese middle-aged and elderly adults. Nutrients. 2023 Sep 15(18), 3974.
Jie Zheng, Fangxiao Cheng, Yage Du, Ying Song, Zhaoming Cao, Mingzi Li, Yanhui Lu*. Metabolic signatures and potential biomarkers in the progression of type 2 diabetes mellitus with cognitive impairment patients: A cross-sectional study. Interdisciplinary Nursing Research. 2023 February 2(1):p 19-26.
Ying Song, Yage Du, Yu An, Jie Zheng, Yanhui Lu*. A systematic review and meta-analysis of cognitive and behavioral tests in rodents treated with different doses of D-ribose. Frontiers in Aging Neuroscience. 2022 Nov 9; 14:1036315.
Yage Du, Xiaoying Li, Yu An, Ying Song, Yanhui Lu*. Association of gut microbiota with sort-chain fatty acids and inflammatory cytokines in diabetic patients with cognitive impairment: A cross-sectional, non-controlled study. Frontiers in Nutrition. 2022 Jul 22; 9:930626.
Yanhui Lu, Hua Jiang, Huijing Zhang, Ruxue Li, Qi Zhang, Dan Luo, Xue Cai, Mingzi Li*. Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum D-ribose and cognitive performance in type 2 diabetic patients. Free Radical Biology and Medicine,2021.05.015.
Yanhui Lu, Pengbo Xing, Xue Cai, Dan Luo, Ruxue Li, Cathy Lloyd, Norman Sartorius, Mingzi Li*, Prevalence and Risk Factors for Diabetic Peripheral Neuropathy in Type 2 Diabetes in 14 Countries: The INTERPRET-DD Study. Frontiers in Public Health. 2020, 8:534372.
Yanhui Lu, Yu An, Chenyan Lv, Weiwei Ma, Yuandi Xi, Rong Xiao*, Dietary soybean isoflavones in Alzheimer’s disease prevention. Asia Pacific Journal of Clinical Nutrition 2018,27(5):946-954.
Yanhui Lu, Xinjun Jiang,Shuling Liu, Mingzi Li*. Changes in cerebrospinal fluid Tau and β-Amyloid levels in diabetic and prediabetic patients: a meta-analysis. Frontiers in Aging Neuroscience. 2018 Oct 11;10:271.
Yanhui Lu, Yu An, Huanling Yu, Fengyuan Che, Xiaona Zhang, Hongguo Rong, Rong Xiao*. Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals. Metabolic brain disease. 2017,32(4):1089-1097.
Yanhui Lu, Yu An, Jin Guo, Xiaona Zhang, Hui Wang, Hongguo Rong, Rong Xiao1*. Dietary intake of nutrients and lifestyle affect the risk of mild cognitive impairment in the Chinese elderly population: a cross-sectional study. Frontiers in behavioural neuroscience. 2016,10:229.
所获奖项：
2023年 北京市优秀农工党员
2019-09 北京大学军训嘉奖令
2019-05 北京大学第18届青年教师教学基本功比赛三等奖
2018-12 北京大学护理学院青年教师比赛一等奖
社会兼职：
中国营养学会营养与免疫分会委员
中国营养学会特殊营养分会委员
中国健康管理协会护理分会常务理事
山东省精神卫生护理专业委员会委员
Nursing Communication杂志主编
中华行为医学与脑科学杂志编委
中西医结合护理杂志(中英文)编委
云南省科技战略(评审)专家
数字化学习技术集成与应用教育部工程研究中心专家委员会委员
