Researcher，Master/doctoral supervisor, Postdoctoral cooperative supervisor

Department: Medical-Surgical Nursing

Tel: 13969955156

Address:38 Xueyuan Road, Haidian District,Beijing, China

E-mail: luyanhui@bjmu.edu.cn

Personal Introduction:

Yanhui Lu, a doctoral supervisor.Her research primarily investigates the mechanisms linking gut microbiota to chronic diseases, alongside the roles of nutrition and clinical nursing within interdisciplinary domains. She has served as the project leader or key member for several national, provincial/ministerial, and university-level projects, including National Natural Science Foundation of China (general program), the project of the Science and Technology Commission of the Central Military Commission, the integration project for major research plan of the National Natural Science Foundation of China, sub-projects of the key project by the Ministry of Science and Technology for “Stem Cell Research and Organ Repair”, youth project of National Natural Science Foundation of China, the first-class funding of Postdoctoral Foundation, youth project of Beijing Municipal Natural Science Foundation and Peking University’s Clinical Medicine X+ Youth Special Project, with total funding amounting to 6.03 million RMB. She has published over 30 SCI papers in high-impact journals such as Nature Communications, Pharmacology Research, and BMC Medicine, among which 20 SCI papers were published as corresponding/first author, and he has obtained 1 invention patent as the first inventor.She currently serves as a member of the Special Nutrition Branch of the Chinese Nutrition Society, a member of the Nutrition and Immunology Branch of the Chinese Nutrition Society, an executive director of the Nursing Branch of the Chinese Health Management Association, the editor-in-chief of the Nursing Communication magazine, the review expert for Yunnan Province science and technology strategy and several other academic part-time positions.

Personal profile (experiences such as Education, Employment, courses you are teaching):

Education:

2018 -2021, Post-doctor, Nursing, Peking University

2014 -2017, Ph.D, Nutrition and Food Hygiene, Capital Medical University

Employment:

2021-2022,Associate professorin the School of Nursing, Peking University

2008 -2014,Head nurse of ICU and Deputy Director of Nursing Department, Linyi Mental Health Center

2004 -2008, Nurse of Emergency Department and ICU, Linyi People’s Hospital

Course teaching:

Functional Assessment and Practice, Internal Medical Nursing, Emergency Nursing

Research Areas:

Nutrition and Chronic Disease Management; Clinical Nursing

Selected projects (including title and fund support):

National Natural Science Foundation of China (General Program): The Role and Mechanism of Intestinal Akkermansia-derived Vitamin B12 in Improving Diabetic Cognitive Impairment through Regulating Neuronal Cell Reprogramming, grant No. 82473618, 2025-2028, Funding: 490,000 yuan, Principal Investigator.

Project of the Science and Technology Commission of the Central Military Commission: Future Advanced Technology, grant No. 232-CXCY-M113-01-03-01, 2023-2025, Funding: 1.2 million yuan, Principal Investigator.

Integration project for major research plan of the National Natural Science Foundation of China, Study in the regulation and intervention strategies of gut microbiota in metabolic diseases, grant No. 92357305, 2024-2026,Funding: 1.03 million yuan, key member of project.

Youth Project of National Natural Science Foundation of China, Novel mechanism of Akk bacterial gavage in regulating NLRP3 inflammasome to improve cognitive impairment induced by type 2 diabetes mellitus, grant No.82003456, 2020-2023, Funding: 240,000 yuan, Principal Investigator

Peking University Clinical Medicine +X Youth Special Project, Mechanism of acetic acid to improve diabetes-induced cognitive impairment by regulating NLRP3 inflammasome through ubiquitination-mitophagy pathway, grant No. PKU2023LCXQ009, 2023, Funding: 290,000 yuan, Principal Investigator.

Sub-projects of the key project by the Ministry of Science and Technology for “Stem Cell Research and Organ Repair”, Mechanisms of Maternal-Fetal Tolerance and Their Application in the Induction of Immune Tolerance in Stem Cell Transplantation, grant No. 2022YFA1103600, 2022-2027, Funding: 1.4 million yuan, key member of project.

First Class Grant of Post-doctoral Project Fund, The effects and mechanism of D-ribosylation on cognitive decline in patients with type 2 diabetes mellitus, grant No. 2018M630048, 2018-2021, Funding: 80,000 yuan,Principal Investigator.

Youth project of Beijing Municipal Natural Science Foundation, The role and mechanism of short-chain fatty acids, metabolites of gut microbiota, in cognitive impairment induced by type 2 diabetes mellitus, grant No.7194284, 2019-2020, Funding: 100,000 yuan,Principal Investigator.

Selected publication:

Tingjing Zhang, Jiangen Song, Zhenfei Shen, Kewan Yin, Feifei Yang, Honghao Yang, Zheng Ma, Liangkai Chen, Yanhui Lu*, Yang Xia*. Associations between different coffee types, neurodegenerative diseases, and related mortality: findings from a large prospective cohort study. The American Journal of Clinical Nutrition. 2024 Aug.

Limin Cao, Yu An, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu*, Liangkai Chen*, Yang Xia*. Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis. BMC Medicine. 2024, 22:101.

Tingjing Zhang, Yu An, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu*, Yang Xia*. Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank. Alzheimer's research & therapy. 2024 May 11;16(1):106.

Yage Du, Yu An, Ying Song, Nan Li, Jie Zheng, Yanhui Lu*. Live and pasteurized Akkermansia muciniphila ameliorates diabetic cognitive impairment by modulating gut microbiota and metabolites in db/db mice. Experimental Neurology. 2024 May 21:114823.

Zhaoming Cao, Yu An, Yanhui Lu*. Altered N6-methyladenosine modification patterns and transcript profiles contributes to cognitive dysfunction in high-fat induced diabetic mice. International Journal of Molecular Sciences. 2024 Feb 6;25(4):1990.

Xin Zhang, Tianzhi Xie, Shuang Zhou, Yingxuan Yuan, Weixuan Chen, Jie Zheng, Xuebo Liu, Tian Yuan*, Yanhui Lu*, Zhigang Liu*. Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids. Food & Function. 2024 Feb 19;15(4):2249-2264.

Jie Zheng#, Yu An#, Yage Du, Ying Song, Qian Zhao, Yanhui Lu*. Effects of short-chain fatty acids on blood glucose and lipid levels in mouse models of diabetes mellitus: a systematic review and network meta-analysis. Pharmacological Research. 2024 Jan;199:107041.

Yage Du, Liuqing Yang, Yu An, Ying Song, Yanhui Lu*. Health-related quality of life and associated factors in elderly individuals with dyslipidemia in rural Northern China. Quality of Life Research. 2023 Dec;32(12):3547-3555.

Chunyou Mao*, Mengru Gao, Shaokun Zang, Yanqing Zhu, Dandan Shen, Linan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Weiwei Wang, Qingya Shen, Yanhui Lu*, Xin Ma*, Yan Zhang*. Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nature Communications. 2023 Nov 22;14(1), 7620.

Yage Du, Qi Zhang, Xiaolan Zhang, Ying Song, Jie Zheng, Yu An*, Yanhui Lu*. Correlation between inflammatory biomarkers, cognitive function and glycemic and lipid profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Clinical Biochemistry. 2023 Nov; 121-122:110683.

Ying Song, Fangxiao Cheng, Yage Du, Jie Zheng, Yu An, Yanhui Lu*. Higher adherence to the AMED, DASH, and CHFP dietary patterns is associated with better cognition among Chinese middle-aged and elderly adults. Nutrients. 2023 Sep 15(18), 3974.

Jie Zheng, Fangxiao Cheng, Yage Du, Ying Song, Zhaoming Cao, Mingzi Li, Yanhui Lu*. Metabolic signatures and potential biomarkers in the progression of type 2 diabetes mellitus with cognitive impairment patients: A cross-sectional study. Interdisciplinary Nursing Research. 2023 February 2(1):p 19-26.

Ying Song, Yage Du, Yu An, Jie Zheng, Yanhui Lu*. A systematic review and meta-analysis of cognitive and behavioral tests in rodents treated with different doses of D-ribose. Frontiers in Aging Neuroscience. 2022 Nov 9; 14:1036315.

Yage Du, Xiaoying Li, Yu An, Ying Song, Yanhui Lu*. Association of gut microbiota with sort-chain fatty acids and inflammatory cytokines in diabetic patients with cognitive impairment: A cross-sectional, non-controlled study. Frontiers in Nutrition. 2022 Jul 22; 9:930626.

Yanhui Lu, Hua Jiang, Huijing Zhang, Ruxue Li, Qi Zhang, Dan Luo, Xue Cai, Mingzi Li*. Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum D-ribose and cognitive performance in type 2 diabetic patients. Free Radical Biology and Medicine. 2021.05.015.

Yanhui Lu, Pengbo Xing, Xue Cai, Dan Luo, Ruxue Li, Cathy Lloyd, Norman Sartorius, Mingzi Li*. Prevalence and risk factors for diabetic peripheral neuropathy in type 2 diabetes in 14 countries: the INTERPRET-DD study. Frontiers in Public Health. 2020; 8:534372.

Yanhui Lu, Yu An, Chenyan Lv, Weiwei Ma, Yuandi Xi, Rong Xiao*. Dietary soybean isoflavones in Alzheimer’s disease prevention. Asia Pacific Journal of Clinical Nutrition. 2018;27(5):946-954.

Yanhui Lu, Xinjun Jiang,Shuling Liu, Mingzi Li*. Changes in cerebrospinal fluid Tau and β-Amyloid levels in diabetic and prediabetic patients: a meta-analysis. Frontiers in Aging Neuroscience. 2018 Oct 11;10:271

Yanhui Lu, Yu An, Huanling Yu, Fengyuan Che, Xiaona Zhang, Hongguo Rong, Rong Xiao*. Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals. Metabolic Brain Disease. 2017;32(4):1089-1097.

Yanhui Lu, Yu An, Jin Guo, Xiaona Zhang, Hui Wang, Hongguo Rong, Rong Xiao*. Dietary intake of nutrients and lifestyle affect the risk of mild cognitive impairment in the Chinese elderly population: a cross-sectional study. Frontiers in Behavioural Neuroscience. 2016; 10:229.

Membership (academic):

Member of the Nutrition and Immunity Branch of the Chinese Nutrition Society

Member of the Special Nutrition Branch of the Chinese Nutrition Society

Executive Director of the Nursing Branch of the Chinese Health Management Association

Member of the Shandong Province Mental Health Nursing Professional Committee

Editor-in-chief of the Nursing Communication magazine

Editorial board member of the Chinese Journal of Behavioral Medicine and Neuroscience

Editorial board member of the Journal of Integrated Nursing (Chinese and English)

Review expert in Yunnan Province Science and Technology Strategy

Member of the Expert Committee on the Integration and Application of Digital Learning