REN, Lihua
Ren, Lihua
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Ren, Lihua |
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Assistant Research Fellow, PhD |
Department: Maternal and Child Nursing Department Tel: 010-82805252 Address: Peking University School of Nursing, No.38 Xueyuan Road, Haidian District, Beijing 100191, P.R. China E-mail: renlihua@bjmu.edu.cn |
Personal Introduction: Dr. Ren Lihua is an associate professor at Peking University School of Nursing. She has a nursing and preventive medicine interdisciplinary background. Her research mainly involves two fields. On one hand, she focuses on the impact of environmental pollution on reproductive health. From the perspective of early life, she explored the effects of environmental pollutants in early life on the reproductive function of offspring and the epigenetics mechanism. On other hand, she focuses on maternal and child health, mainly focusing on early life health management, and the impact of early life environment on maternal and child outcomes. |
Personal profile: Educational experiences Sep, 2014~ Jul, 2017 Doctor, School of Public health, Capital Medical University, China Sep, 2008~ Dec, 2011 Master, School of Nursing, Xinxiang Medical University, China Sep, 2001~ Jul, 2006 Bachelor, School of Nursing, Jilin University, China Working experiences Oct, 2020~ Associate professor, School of Nursing, Peking University, China Oct, 2017~ Oct, 2020 Postdoctor, School of Nursing, Peking University, China Jul, 2006~ Aug, 2014 ecturer, School of Nursing, Xinxiang Medical University, China |
Research Areas: Environment and reproductive health, Maternal and child health |
Selected projects (including title and fund support): Transgenerational male reproductive toxicity of exposure to silica nanoparticles in early-life stages and the role of METTL3/miR-494/CREM. Supported by Peking University Medicine Sailing Program for Young Scholars’ Scientific & Technological Innovation.No: BMU2024YFJHPY036, 2024 (PI). Modification on cardiovascular effects of short-term exposure to black carbon by psychosocial stress and its regulatory mechanism via glucocorticoid secretion and glucocorticoid receptor methylation. Supported by National Natural Science Foundation of China. No: 82073509, 2021-2024 (Co-PI). The effects of the fine particulate matter on reproduction of male rats in early life stage and the mechanism. Supported by the Fundamental Research Funds for the Central Universities. No: BMU2021YJ020, 2021-2023 (PI) The transgenerational effects of the fine particulate matter on reproduction of male rats in early life stage and the role of methylation of inhibin. Supported by National Natural Science Foundation of China. No: 81803273, 2019-2021 (PI). The effect and mechanism of PM2.5 on spermatogenesis by miR-200b-3p-mediated autophagy. Supported by China Postdoctoral Science Foundation. No:2018M641119, 2018-2020 (PI) Effect of PM2.5 exposure during pregnancy on birth weight and regulation mechanism of thyroglobulin hydrolase. Supported by LANGTAI Nursing Research Fund. No: LTHL18MS01, 2018-2019 (PI) |
Selected publication (no more than 10 papers) : Yinchu Hu, Meidi Shen, Chongkun Wang, Qifang Huang, Ruiqiong Li, Gantuya Dorj, Enkhjargal Gombojav, Jiwei Du, Lihua Ren*. A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals. J Hazard Mater. 2024 Mar 5;465:133375. （IF=12.2） Wang C, Li J, Li J, Li Y, Li C, Ren L*. What can be done to protect toddlers from air pollution: Current evidence. J Pediatr Nurs. 2024 May-Jun;76:e50-e59. Zhao M, Zhou G, Wang J, Zhang Y, Xue J, Liu J, Xie J, Ren L#, Zhou X#. MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells. Nanotoxicology. 2023 Jun 14:1-13 Huang J, Lu H, Du J, Zhang L, Wei J, Huang Q, Wu S, Zhou X, Ren L*. Effects of exposure to PM2.5 during pregnancy on the multigenerational reproductive outcomes of male mouse offspring and the role of Sertoli cells. Environ Sci Pollut Res Int. 2023 Sep 11. Jianhui Liu, Jing Huang, Leqiang Gao, Yujian Sang, Xiangyang Li, Guiqing Zhou, Linlin Cao, Hong Lu, Xianqing Zhou*, Lihua Ren*. Maternal exposure to PM2.5 disrupting offspring spermatogenesis through induced sertoli cells apoptosis via inhibin B hypermethylation in mice. Ecotoxicology and Environmental Safety, 2022 Jun; 241: 113760. Qi-Fang Huang, Yin-Chu Hu, Chong-Kun Wang, Jing Huang, Mei-Di Shen, Li-Hua Ren*. Clinical First-Trimester Prediction Models for Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Biological Research For Nursing 2022, Vol. 0(0) 1–13 （Q2） Guiqing Zhou #, Lihua Ren#, Haiping Yin, Jianhui Liu, Xiangyang Li, Ji Wang, Yanbo Li, Yujian Sang, Yanzhi Zhao*, Xianqing Zhou*, Zhiwei Sun. The alterations of miRNA and mRNA expression profile and their integration analysis induced by silica nanoparticles in spermatocyte cells. NanoImpact, 2021, 23 :100348. (IF=6.038)（Q1） Lihua Ren, Jing Huang, Jialiu Wei, Yu Zang, Yang Zhao, Shaowei Wu, Xiaohong Zhao, Xianqing Zhou, Zhiwei Sun, Hong Lu*. Maternal exposure to fine particle matters cause autophagy via UPR-mediated PI3K-mTOR pathway in testicular tissue of adult male mice in offspring. Ecotoxicology and Environmental Safety. 2020 Feb;189:109943. (IF=7.129)（Q1） Ren L, Liu J, Zhang J, Wang J, Wei J, Li Y, Guo C, Sun Z, Zhou X*.Silica nanoparticles induce spermatocyte cell autophagy through microRNA-494 targeting AKT in GC-2spd cells. Environment Pollution. 2019 Sep 11; 255:113172. (IF=9.988) （Q1） Ren L, Zhang J, Wang J, Wei J, Liu J, Li X, Zhu Y, Li Y, Guo C, Duan J, Sun Z, Zhou X*. Silica nanoparticles induce spermatocyte cell apoptosis through microRNA-2861 targeting death receptor pathway. Chemosphere. 2019, 228:709 -720. (IF=8.943) （Q1） |
Membership (academic): Vice-chairman，Beijing International Economic Ecology Association Expert of National Graduate Education Evaluation and Monitoring Expert Database Standing member, Environmental and Reproductive Health Branch, China Eugenics Association |
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